Ultrastructural studies of ciliated cells in the respiratory tract of common marmosets

The ciliated cells of the respiratory epithelium play an important role in the pulmonary mucociliary clearance mechanisms. Ultrastructural changes in the cilia of these cells can therefore be an expression of pathogenetic processes in the context of respiratory diseases. Against this background, ultrastructural indications of ciliary dyskinesia in common marmosets (Callithrix jacchus) of different ages and taking into account clinically inapparent pulmonary changes were determined in the present work in order to make a contribution to the validation of common marmosets as an animal model for chronic respiratory diseases in humans (COPD /asthma). Ciliary alterations occurred predominantly with an incidence of less than 1% (mean: 0.06% - 0.55%). These results indicate that the cilia changes found are of a secondary nature and are subject to an individual range of variation. They occur regularly in healthy animals and are equally observed in animals with histologically diagnosed alterations confined to the alveolar region. Analysis of the trachea by scanning electron microscopy revealed a non-homogeneous distribution of the ciliated cells, regardless of age or the histological findings in the lungs. While ciliated cells dominated in the cartilage-free area of ​​the trachea, non-ciliated, microvilli-bearing epithelial cells were predominantly found in the cartilage areas. The results of the present work must be taken into account when evaluating the common marmoset as an animal model for chronic respiratory diseases in humans and serve as reference data for the interpretation of ultrastructural studies on the respiratory tract.

Details

• Title: Ultrastructural studies on ciliated cells
• Subtitle: in the respiratory tract of common marmosets (Callithrix jacchus) with and without lung diseases
• Author: Dr. Rebecca Hoffmann
• Edition: 1st edition
• Published: 1st edition 29.11.2011
• Discipline: Veterinary Medicine
• Product Type: Book (Hardcover)
• Product type: Dissertation
• Language: German
• Binding: Softcover (paperback)
• Dimensions: 21.0 x 14.8 cm (DIN A5)
• Scope: 108 pages
• Condition: New (shrink-wrapped in foil)
• Keywords: Callithrix jacchus, compound cilia, COPD/asthma research, extra matrix, extra tubules, interstitial pneumonia, pars cartilaginea, pars membranacea, scanning electron microscopy, secondary cilia changes, tracheal cilia, transmission electron microscopy, distribution of ciliated cells, marmoset, cilia, ciliated cell , ciliary disorientation

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