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The present dissertation is focused on the phylogenetic, biochemical, structural and physiological analysis of the hydratases from Streptococcus pyogenes M49 and Lactobacillus acidophilus NCFM. These hydratases belong to myosin cross-reactive antigen (MCRA) protein family for which knowledge on the biochemical and physiological function is scarce. This study provides the first line of evidence on biological significance of this protein family as ubiquitous bacterial enzymes which metabolize highly toxic unsaturated fatty acids to their less toxic and more soluble hydroxy derivatives....

Among the Gram-negative pathogens, Escherichia coli(E. coli) is the main cause of nosocomial infections. As a result of antibiotic therapies, resistance develops, in E. coli mainly against beta-lactam antibiotics such as penicillins and cephalosporins (ESBL producers). This work describes the molecular genetic causes that contribute to the dissemination of cephalosporin resistance genes, blaCTX-M. Based on a collection of E. coli isolates from nosocomial infections, it could be shown that in addition to clonal spread of cephalosporin-resistant E. coli strains also...