Genetic background for the spread of the extended-spectrum beta-lactamase gene blaCTX-M in Escherichia coli
- Brand: Cullik, Dr. Angela
- Availability: In stock
- SKU: 9783941274624
€39,90
Among the Gram-negative pathogens, Escherichia coli(E. coli) is the main cause of nosocomial infections. As a result of antibiotic therapies, resistance develops, in E. coli mainly against beta-lactam antibiotics such as penicillins and cephalosporins (ESBL producers). This work describes the molecular genetic causes that contribute to the dissemination of cephalosporin...
Among the Gram-negative pathogens, Escherichia coli(E. coli) is the main cause of nosocomial infections. As a result of antibiotic therapies, resistance develops, in E. coli mainly against beta-lactam antibiotics such as penicillins and cephalosporins (ESBL producers). This work describes the molecular genetic causes that contribute to the dissemination of cephalosporin resistance genes, blaCTX-M. Based on a collection of E. coli isolates from nosocomial infections, it could be shown that in addition to clonal spread of cephalosporin-resistant E. coli strains also have specific mobile genetic elements (MGE), including IS26 transposons, that play a crucial role in the spread of resistance genes. Furthermore, the importance of plasmids and their molecular structures in the stable transmission of resistance genes in E. coli received.
Details
- Title: Genetic background for the spread of the extended-spectrum beta-lactamase gene blaCTX-M in Escherichia coli
- Author: Dr. Angela Cullik
- Edition: 1st edition
- Published: 1st edition 12/31/2010
- Subject: Biology
- Product Type: Book (Hardcover)
- Product type: Dissertation
- Language: German
- Binding: Softcover (paperback)
- Dimensions: 21.0 x 14.8 cm (DIN A5)
- Extent: XII / 174 pages
- Condition: New (shrink-wrapped in foil)
- Keywords: antibiotics, cefotaxime, cefpodoxime, cephalosporins, CTX-M, E. coli O25, ESBL, Escherichia coli, extended spectrum beta-lactamases, H4 ST131, IncN, insertion elements, IS26, ISEcp1, MGE, MIC, minimal Inhibitory concentration, mobile genetic elements, nosocomial infections, penicillins, plasmids, plasmid sequencing, resistance, sulbactam, transposons
Author
The author, Angela Cullik, has been dealing with the highly topical issue of antibiotic resistance of enterobacteria from hospital infections since completing her university degree in biology in 2006. After completing her diploma thesis at the Institute for Pharmaceutical Biology at the University of Hamburg, she moved to the Robert Koch Institute as a research assistant, where she completed her dissertation in 2010 in the field of nosocomial infections.
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